NEW YORK, NY—via eTeligis—LifeSci Advisors, LLC announcement for Cynapsus Therapeutics, Inc. (TSX VENTURE: CTH) (OTCQX: CYNAF)
- Sublingual Apomorphine Therapy Designed to Treat Parkinson's Disease Freezing Episodes
- Following Positive Phase I Results, Cynapsus is Pursuing 505(b)(2) Approval for APL-130277
- Report Available for Download at http://www.lifesciadvisors.com/clients/cynapsus/
LifeSci Advisors, LLC, a leading provider of investment research and investor relations services in the life sciences sector, today announced that it has initiated coverage of Cynapsus Therapeutics, Inc. (TSX VENTURE: CTH) (OTCQX: CYNAF), a company developing APL-130277, a unique thin-film sublingual formulation of apomorphine to treat freezing episodes in Parkinson's disease. The sublingual strip is intended to replace a painful subcutaneous injection that is currently the only available rescue therapy for these episodes. The Company recently reported positive results from a Phase I pharmacokinetic study. Pivotal efficacy studies in apomorphine-naïve and apomorphine-experienced PD patients are expected to begin in the fourth quarter of 2014, followed by a safety study in 2015, leading to a potential regulatory filing in early 2016.
"The sublingual strip that Cynapsus is developing has the potential to substantially improve the treatment of 'off' episodes for Parkinson's patients while also helping them avoid painful injections," said Andrew I. McDonald, Ph.D., Founding Partner at LifeSci Advisors. "Injection site reactions and the difficulty of self-administration have hampered subcutaneous apomorphine, and created an unmet medical need. The sublingual formulation has much greater potential to penetrate the market."
On January 13 Cynapsus reported positive results from a Phase I, CTH-103, comparing the pharmacokinetic profile of three doses of sublingual apomorphine to subcutaneous injections. Results showed a stronger safety profile for APL-130277 as compared to subcutaneous injection, which should enable Cynapsus to pursue a differentiated label from injectable apomorphine with possibly better safety claims under 505(b)(2) regulatory approval.
In a 35 page Initiation Report by LifeSci Advisors, we explain the potential advantages of Cynapsus' sublingual formulation of apomorphine over the subcutaneous injection and other products in development. The report explores the scientific basis for using apomorphine to treat 'off' episodes in Parkinson's disease patients. The addressable market is discussed, as well as the potential for APL-130277 to increase the number of patients using apomorphine to treat these episodes.
Dr. McDonald's full Initiation Report is available to download at no cost at the LifeSci Advisors website, www.lifesciadvisors.com. In addition to this Initiation Report, LifeSci Advisors will also provide ongoing coverage and event-based research updates on the Company as developments occur.
The LifeSci Advisors research team is led by Dr. Andrew I. McDonald, an industry veteran with more than 15 years of healthcare industry experience. Prior to co-founding LSA, Dr. McDonald was the Senior Biotechnology Analyst at Great Point Partners, a leading health care investment firm with over $500 million under management. Before Great Point, he was Co-Head of Healthcare Research and Lead Biotechnology Analyst at ThinkEquity Partners, a boutique investment banking firm focused on growth companies. Dr. McDonald holds a Ph.D. in organic chemistry from the University of California, Irvine, and, earlier in his career, worked as a medicinal chemist at both Pfizer and Cytokinetics.
About LifeSci Advisors:
LifeSci Advisors (LSA) is a leading research firm and communications consultancy dedicated to the life sciences industry. The firm provides strategic counsel, customized marketing communications, comprehensive research reports and investor relations services to companies that specialize in the discovery, development and commercialization of drugs, drug delivery systems, medical devices and diagnostics. To learn more about LSA, visit the company's website, www.lifesciadvisors.com.
Important Disclosures:
The research report described in this press release is not intended as an offering, recommendation, or a solicitation of an offer to buy or sell securities. The securities discussed in LSA research reports may be unsuitable for some investors depending on their specific investment objectives, financial status, risk profile, or particular needs. Investors should consider LSA reports as only a single factor in making their investment decisions and should not rely solely on these reports in evaluating whether or not to buy or sell the securities of the subject company. LifeSci Advisors has been compensated by the company that is the subject of the report described and future research reports, investor relations services, and general consulting services. Please read each report's full disclosures and analyst background on the LSA website, www.lifesciadvisors.com, before investing. LifeSci Advisors is not a registered investment adviser or broker-dealer.
Forward-looking statements:
This press release contains forward-looking statements subject to risks and uncertainties that could cause actual results to differ materially from those projected. These forward-looking statements represent LSA's judgment as of the date of this release. LifeSci Advisors disclaims, however, any intent or obligation to update these forward-looking statements.
Media Contact:
Michael Rice
Phone: (646) 597-6979
Email: mrice@lifesciadvisors.com
Cynapsus Therapeutics Contact:
Anthony Giovinazzo
President and CEO
Phone: (416) 703-2449 x225
Email: ajg@cynapsus.ca
SOURCE: LifeSci Advisors
Associated Documentation:
Link to submission on http://www.eteligis.com
LifeSci_2-7-14_ETL_KMG.docx
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